Cystic dilatation of
peribiliary glands of intrahepatic and extrahepatic bile ducts was investigated
in autopsied livers with adult polycystic disease (n = 8), in autopsied
livers with solitary nonparasitic cysts (n = 18) and in normal autopsied
livers (n = 23). In normal livers, cystic dilatation of intrahepatic peribiliary
glands was absent or slight, when present. In livers with solitary nonparasitic
cysts, cystic dilatation of intrahepatic peribiliary glands was present
in varying degrees. In livers with adult polycystic disease, intrahepatic
peribiliary glands showed frequent and severe cystic dilatation so marked
that it was grossly recognizable. In contrast, peribiliary glands of the
extrahepatic bile ducts showed no cystic dilatation in most cases, regardless
of the three conditions examined. Liver parenchymal cysts were numerous
in livers with adult polycystic disease, few in livers with solitary nonparasitic
cysts and nonexistent in normal livers. Von Meyenburg complexes were present
in 87.5% of livers with adult polycystic disease, in 16.7% of livers with
solitary nonparasitic cysts and in 4.3% of normal livers. These findings
suggest that intrahepatic peribiliary glands undergo cystic dilatation
in livers with adult polycystic disease-and, to a lesser degree and frequency
in livers with solitary nonparasitic cysts, probably because of congenital
or genetic factors-and that these cystic changes may comprise a part of
numerous cysts of adult polycystic disease.
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