Ebara M, Fukuda H, Kojima Y, Morimoto N, Yoshikawa M, Sugiura N, Satoh T, Kondo F, Yukawa M, Matsumoto T, Saisho H.: Small hepatocellular carcinoma: relationship of signal intensity to histopathologic findings and metal content of the tumor and surrounding hepatic parenchy Radiology. 1999 Jan;210(1):81-8.
PURPOSE: To investigate
the relationship between the metal content of hepatocellular carcinoma
(HCC) and the signal intensity pattern on magnetic resonance images.
MATERIALS AND METHODS: The signal intensity patterns of 59 HCCs
3 cm in diameter or smaller were correlated with histologic findings
and metal content. RESULTS: HCCs with high signal intensity on
T1-weighted images demonstrated more steatosis (P = .035) and
higher copper content (P = .008) than did surrounding hepatic
parenchyma. HCCs with high signal intensity on T2-weighted images
demonstrated more clear cells (P = .001) than did surrounding
hepatic parenchyma. The higher signal intensities on T1-weighted
and T2-weighted images were related to a higher and a lower degree
of histologic differentiation, respectively. Multivariate analysis
showed that the contrast-to-noise ratio between the HCC and surrounding
hepatic parenchyma was affected by intratumoral copper content
(P = .0338), zinc content of surrounding hepatic parenchyma (P
= .0379), and the degree of histologic differentiation on T1-weighted
(P = .0031) and T2-weighted (P = .0062) images. CONCLUSION: The
signal intensity of HCC on T1-weighted images is related to the
degree of histologic differentiation, intratumoral copper content,
and zinc content of surrounding hepatic parenchyma, whereas the
signal intensity on T2-weighted images is related to the degree
of histologic differentiation.
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