Hori M, Murakami T, Kim T, Tsuda K, Takahashi S, Okada A, Takamura M, Nakamura H. Detection of hypervascular hepatocellular carcinoma: comparison of SPIO-enhanced MRI with dynamic helical CT. J Comput Assist Tomogr. 2002 Sep-Oct;26(5):701-10.
PURPOSE: The purpose
of this study was to compare the diagnostic performance of superparamagnetic
iron oxide (SPIO)-enhanced MRI for the detection of hypervascular
hepatocellular carcinoma (HCC) with dynamic helical CT. METHODS:
SPIO-enhanced MR and dynamic helical CT images obtained from 41
patients with 52 hypervascular HCCs (5-130 mm; mean, 27 mm) were
retrospectively analyzed. MRI were obtained with 1.5 T scanners
using T2-weighted and proton density-weighted spin-echo (or fast
spin-echo) sequences for all cases and a T2*-weighted gradient
echo sequence for 36 cases. Four blinded observers reviewed images
independently. Diagnostic accuracy was evaluated using alternative-free
response receiver operating characteristic (AFROC) method. Sensitivities
and positive predictive values (PPV) were also evaluated. RESULTS:
The areas under the AFROC curves for each observer were greater
for MR than for CT (means, 0.81 and 0.76; p < 0.05). The mean
sensitivities for MR and CT were 0.75 and 0.71, respectively (p
= 0.13). The mean PPVs were 0.83 and 0.79 (p = 0.21). CONCLUSION:
SPIO-enhanced MRI showed slightly better diagnostic performance
than dynamic helical CT for the detection of hypervascular HCCs.
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